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Cofactor Biogenesis in Cysteamine Dioxygenase: C-F Bond Cleavage with Genetically Incorporated Unnatural Tyrosine

Cysteamine dioxygenase (ADO) is a thiol dioxygenase whose study has been stagnated by ambiguity as to whether or not it possesses an anticipated protein-derived cofactor. Reported herein is the discovery and elucidation of a Cys-Tyr cofactor in human ADO, crosslinked between Cys220 and Tyr222 throug...

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Detalhes bibliográficos
Publicado no:Angew Chem Int Ed Engl
Main Authors: Wang, Yifan, Griffith, Wendell P., Li, Jiasong, Koto, Teruaki, Wherritt, Daniel J., Fritz, Elizabeth, Liu, Aimin
Formato: Artigo
Idioma:Inglês
Publicado em: 2018
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6019576/
https://ncbi.nlm.nih.gov/pubmed/29752763
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/anie.201803907
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