Synthetic Standards Combined With Error and Bias Correction Improve the Accuracy and Quantitative Resolution of Antibody Repertoire Sequencing in Human Naïve and Memory B Cells

High-throughput sequencing of immunoglobulin (Ig) repertoires (Ig-seq) is a powerful method for quantitatively interrogating B cell receptor sequence diversity. When applied to human repertoires, Ig-seq provides insight into fundamental immunological questions, and can be implemented in diagnostic a...

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Detalhes bibliográficos
Publicado no:Front Immunol
Main Authors: Friedensohn, Simon, Lindner, John M., Cornacchione, Vanessa, Iazeolla, Mariavittoria, Miho, Enkelejda, Zingg, Andreas, Meng, Simon, Traggiai, Elisabetta, Reddy, Sai T.
Formato: Artigo
Idioma:Inglês
Publicado em: Frontiers Media S.A. 2018
Assuntos:
Immunology
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6019461/
https://ncbi.nlm.nih.gov/pubmed/29973938
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fimmu.2018.01401
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