DNA damage response induced by Etoposide promotes steroidogenesis via GADD45A in cultured adrenal cells

Glucocorticoid production is regulated by adrenocorticotropic hormone (ACTH) via the cyclic adenosine monophosphate (cAMP)/protein kinase A (PKA) pathway in the adrenal cortex, but the changes in steroidogenesis associated with aging are unknown. In this study, we show that cell-autonomous steroidog...

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Pubblicato in:Sci Rep
Autori principali: Tamamori-Adachi, Mimi, Koga, Akane, Susa, Takao, Fujii, Hiroko, Tsuchiya, Masao, Okinaga, Hiroko, Hisaki, Harumi, Iizuka, Masayoshi, Kitajima, Shigetaka, Okazaki, Tomoki
Natura: Artigo
Lingua:Inglês
Pubblicazione: Nature Publishing Group UK 2018
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Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC6018231/
https://ncbi.nlm.nih.gov/pubmed/29941883
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41598-018-27938-5
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