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Chiral Thioxanthones as Modulators of P-glycoprotein: Synthesis and Enantioselectivity Studies

Recently, thioxanthone derivatives were found to protect cells against toxic P-glycoprotein (P-gp) substrates, acting as potent inducers/activators of this efflux pump. The study of new P-gp chiral modulators produced from thioxanthone derivatives could clarify the enantioselectivity of this ABC tra...

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Detalhes bibliográficos
Publicado no:Molecules
Main Authors: Lopes, Ana, Martins, Eva, Silva, Renata, Pinto, Madalena M. M., Remião, Fernando, Sousa, Emília, Fernandes, Carla
Formato: Artigo
Idioma:Inglês
Publicado em: MDPI 2018
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6017912/
https://ncbi.nlm.nih.gov/pubmed/29534440
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3390/molecules23030626
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