The Fungal Metabolite Eurochevalierine, a Sequiterpene Alkaloid, Displays Anti-Cancer Properties through Selective Sirtuin 1/2 Inhibition

NAD(+)-dependent histone deacetylases (sirtuins) are implicated in cellular processes such as proliferation, DNA repair, and apoptosis by regulating gene expression and the functions of numerous proteins. Due to their key role in cells, the discovery of small molecule sirtuin modulators has been of...

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Détails bibliographiques
Publié dans:Molecules
Auteurs principaux: Schnekenburger, Michael, Mathieu, Véronique, Lefranc, Florence, Jang, Jun Young, Masi, Marco, Kijjoa, Anake, Evidente, Antonio, Kim, Hyun-Jung, Kiss, Robert, Dicato, Mario, Han, Byung Woo, Diederich, Marc
Format: Artigo
Langue:Inglês
Publié: MDPI 2018
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Article
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC6017873/
https://ncbi.nlm.nih.gov/pubmed/29401749
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3390/molecules23020333
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