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Indole-3-Carbonitriles as DYRK1A Inhibitors by Fragment-Based Drug Design
Dual-specificity tyrosine phosphorylation-regulated kinase 1A (DYRK1A) is a potential drug target because of its role in the development of Down syndrome and Alzheimer’s disease. The selective DYRK1A inhibitor 10-iodo-11H-indolo[3,2-c]quinoline-6-carboxylic acid (KuFal194), a large, flat and lipophi...
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| Udgivet i: | Molecules |
|---|---|
| Main Authors: | , , , , , , |
| Format: | Artigo |
| Sprog: | Inglês |
| Udgivet: |
MDPI
2018
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| Fag: | |
| Online adgang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6017736/ https://ncbi.nlm.nih.gov/pubmed/29364148 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3390/molecules23020064 |
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