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Design, Synthesis, and Biological Evaluation of Axitinib Derivatives

Axitinib is an approved kinase inhibitor for the therapy of advanced metastatic renal cell carcinoma (RCC). It prevents angiogenesis, cellular adhesion, and induces apoptosis of cancer cells. Here, nine axitinib derivatives were designed by replacing the C=C moiety with the N=N group, and the substi...

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Bibliografski detalji
Izdano u:Molecules
Glavni autori: Wei, Na, Liang, Jianqing, Peng, Shengming, Sun, Qiang, Dai, Qiuyun, Dong, Mingxin
Format: Artigo
Jezik:Inglês
Izdano: MDPI 2018
Teme:
Online pristup:https://ncbi.nlm.nih.gov/pmc/articles/PMC6017704/
https://ncbi.nlm.nih.gov/pubmed/29570686
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3390/molecules23040747
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