Design, Synthesis, and Biological Evaluation of 6-Benzoxazole Benzimidazole Derivatives with Antihypertension Activities

[Image: see text] A series of new angiotensin II receptor 1 antagonists were prepared. They displayed nanomolar affinity to AT(1) receptor and could decrease blood pressure efficiently in spontaneously hypertensive rats. Among them, compounds 1b and 2b could reduce the blood pressure with more or eq...

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Veröffentlicht in:ACS Med Chem Lett
Hauptverfasser: Wu, Zhuo, Bao, Xiao-Lu, Zhu, Wei-Bo, Wang, Yan-Hui, Phuong Anh, Nguyen Thi, Wu, Xiao-Feng, Yan, Yi-Jia, Chen, Zhi-Long
Format: Artigo
Sprache:Inglês
Veröffentlicht: American Chemical Society 2018
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6331155/
https://ncbi.nlm.nih.gov/pubmed/30655944
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acsmedchemlett.8b00335
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