Design, Synthesis, and Biological Evaluation of Novel 1,3,4-Thiadiazole Derivatives as Potential Antitumor Agents against Chronic Myelogenous Leukemia: Striking Effect of Nitrothiazole Moiety

In an attempt to develop potent antitumor agents, new 1,3,4-thiadiazole derivatives were synthesized and evaluated for their cytotoxic effects on multiple human cancer cell lines, including the K562 chronic myelogenous leukemia cell line that expresses the Bcr-Abl tyrosine kinase. N-(5-Nitrothiazol-...

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Veröffentlicht in:Molecules
Hauptverfasser: Altıntop, Mehlika Dilek, Ciftci, Halil Ibrahim, Radwan, Mohamed O., Sever, Belgin, Kaplancıklı, Zafer Asım, Ali, Taha F. S., Koga, Ryoko, Fujita, Mikako, Otsuka, Masami, Özdemir, Ahmet
Format: Artigo
Sprache:Inglês
Veröffentlicht: MDPI 2017
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Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6017545/
https://ncbi.nlm.nih.gov/pubmed/29280989
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3390/molecules23010059
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