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A stress-induced response complex (SIRC) shuttles miRNAs, siRNAs, and oligonucleotides to the nucleus

Although some information is available for specific subsets of miRNAs and several factors have been shown to bind oligonucleotides (ONs), no general transport mechanism for these molecules has been identified to date. In this work, we demonstrate that the nuclear transport of ONs, siRNAs, and miRNAs...

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Detalhes bibliográficos
Publicado no:Proc Natl Acad Sci U S A
Main Authors: Castanotto, Daniela, Zhang, Xiaowei, Alluin, Jessica, Zhang, Xizhe, Rüger, Jacqueline, Armstrong, Brian, Rossi, John, Riggs, Arthur, Stein, C. A.
Formato: Artigo
Idioma:Inglês
Publicado em: National Academy of Sciences 2018
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6016802/
https://ncbi.nlm.nih.gov/pubmed/29866826
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1721346115
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