Targeting the potent Beclin 1–UVRAG coiled-coil interaction with designed peptides enhances autophagy and endolysosomal trafficking

The Beclin 1–Vps34 complex, known as “mammalian class III PI3K,” plays essential roles in membrane-mediated transport processes including autophagy and endosomal trafficking. Beclin 1 acts as a scaffolding molecule for the complex and readily transits from its metastable homodimeric state to interac...

Descrizione completa

Salvato in:
Dettagli Bibliografici
Pubblicato in:Proc Natl Acad Sci U S A
Autori principali: Wu, Shuai, He, Yunjiao, Qiu, Xianxiu, Yang, Wenchao, Liu, Wenchao, Li, Xiaohua, Li, Yan, Shen, Han-Ming, Wang, Renxiao, Yue, Zhenyu, Zhao, Yanxiang
Natura: Artigo
Lingua:Inglês
Pubblicazione: National Academy of Sciences 2018
Soggetti:
PNAS Plus
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC6016778/
https://ncbi.nlm.nih.gov/pubmed/29866835
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1721173115
Tags: Aggiungi Tag
Nessun Tag, puoi essere il primo ad aggiungerne! !

Documenti analoghi