Targeting the potent Beclin 1–UVRAG coiled-coil interaction with designed peptides enhances autophagy and endolysosomal trafficking

The Beclin 1–Vps34 complex, known as “mammalian class III PI3K,” plays essential roles in membrane-mediated transport processes including autophagy and endosomal trafficking. Beclin 1 acts as a scaffolding molecule for the complex and readily transits from its metastable homodimeric state to interac...

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Detalhes bibliográficos
Publicado no:Proc Natl Acad Sci U S A
Main Authors: Wu, Shuai, He, Yunjiao, Qiu, Xianxiu, Yang, Wenchao, Liu, Wenchao, Li, Xiaohua, Li, Yan, Shen, Han-Ming, Wang, Renxiao, Yue, Zhenyu, Zhao, Yanxiang
Formato: Artigo
Idioma:Inglês
Publicado em: National Academy of Sciences 2018
Assuntos:
PNAS Plus
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6016778/
https://ncbi.nlm.nih.gov/pubmed/29866835
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1721173115
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