Imperfect interface of Beclin1 coiled-coil domain regulates homodimer and heterodimer formation with Atg14L and UVRAG

Beclin 1 is a core component of the Class III Phosphatidylinositol 3-Kinase VPS34 complex. The coiled coil domain of Beclin 1 serves as an interaction platform for assembly of distinct Atg14L- and UVRAG-containing complexes to modulate VPS34 activity. Here we report the crystal structure of the coil...

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Detalhes bibliográficos
Main Authors: Li, Xiaohua, He, Liqiang, Che, Ka Hing, Funderburk, Sarah F., Pan, Lifeng, Pan, Nina, Zhang, Mingjie, Yue, Zhenyu, Zhao, Yanxiang
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Pub. Group 2012
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3293417/
https://ncbi.nlm.nih.gov/pubmed/22314358
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/ncomms1648
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