Efficiency and Specificity of Targeted Integration Mediated by the Adeno-Associated Virus Serotype 2 Rep 78 Protein

The adeno-associated virus serotype 2 (AAV2) Rep 78 protein, a strand-specific endonuclease (nickase) promotes site-specific integration of transgene sequences bearing homology arms corresponding to the AAVS1 safe harbor locus. To investigate the efficiency and specificity of this approach, plasmid-...

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Udgivet i:Hum Gene Ther Methods
Main Authors: Li, Pingjuan, Marino, Michael P., Zou, Jizhong, Argaw, Takele, Morreale, Michael T., Iaffaldano, Brian J., Reiser, Jakob
Format: Artigo
Sprog:Inglês
Udgivet: Mary Ann Liebert, Inc. 2018
Fag:
Research Articles
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6016731/
https://ncbi.nlm.nih.gov/pubmed/29860898
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1089/hgtb.2018.052
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