A novel inhibitor of pyruvate dehydrogenase kinase stimulates myocardial carbohydrate oxidation in diet-induced obesity

The pyruvate dehydrogenase complex (PDC) is a key control point of energy metabolism and is subject to regulation by multiple mechanisms, including posttranslational phosphorylation by pyruvate dehydrogenase kinase (PDK). Pharmacological modulation of PDC activity could provide a new treatment for d...

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Bibliographische Detailangaben
Veröffentlicht in:J Biol Chem
Hauptverfasser: Wu, Cheng-Yang, Satapati, Santhosh, Gui, Wenjun, Wynn, R. Max, Sharma, Gaurav, Lou, Mingliang, Qi, Xiangbing, Burgess, Shawn C., Malloy, Craig, Khemtong, Chalermchai, Sherry, A. Dean, Chuang, David T., Merritt, Matthew E.
Format: Artigo
Sprache:Inglês
Veröffentlicht: American Society for Biochemistry and Molecular Biology 2018
Schlagworte:
Metabolism
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6016455/
https://ncbi.nlm.nih.gov/pubmed/29739849
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.RA118.002838
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