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Selective Blockade of PGE(2) EP1 Receptor Protects Brain against Experimental Ischemia and Excitotoxicity, and Hippocampal Slice Cultures against Oxygen-Glucose Deprivation
Cyclooxygenase-2 (COX-2) enzyme increases abnormally during excitotoxicity and cerebral ischemia and promotes neurotoxicity. Although COX-2 inhibitors could be beneficial, they have significant side effects. We and others have shown that the EP1 receptor is important in mediating PGE(2) toxicity. He...
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| Publicat a: | Neurotox Res |
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| Autors principals: | , , , , |
| Format: | Artigo |
| Idioma: | Inglês |
| Publicat: |
2008
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| Matèries: | |
| Accés en línia: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6015740/ https://ncbi.nlm.nih.gov/pubmed/19073437 |
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