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Selective Blockade of PGE(2) EP1 Receptor Protects Brain against Experimental Ischemia and Excitotoxicity, and Hippocampal Slice Cultures against Oxygen-Glucose Deprivation

Cyclooxygenase-2 (COX-2) enzyme increases abnormally during excitotoxicity and cerebral ischemia and promotes neurotoxicity. Although COX-2 inhibitors could be beneficial, they have significant side effects. We and others have shown that the EP1 receptor is important in mediating PGE(2) toxicity. He...

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Detalhes bibliográficos
Publicado no:Neurotox Res
Main Authors: AHMAD, ABDULLAH SHAFIQUE, KIM, YUN TAI, AHMAD, MUZAMIL, MARUYAMA, TAKAYUKI, DORÉ, SYLVAIN
Formato: Artigo
Idioma:Inglês
Publicado em: 2008
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Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6015740/
https://ncbi.nlm.nih.gov/pubmed/19073437
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