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Why do disordered and structured proteins behave differently in phase separation?

Intracellular membraneless organelles and their myriad cellular functions have garnered tremendous recent interest. It is becoming well accepted that they form via liquid-liquid phase separation (LLPS) of protein mixtures (often including RNA), where the organelles correspond to a protein-rich, drop...

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Dettagli Bibliografici
Pubblicato in:Trends Biochem Sci
Autori principali: Zhou, Huan-Xiang, Nguemaha, Valery, Mazarakos, Konstantinos, Qin, Sanbo
Natura: Artigo
Lingua:Inglês
Pubblicazione: 2018
Soggetti:
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC6014895/
https://ncbi.nlm.nih.gov/pubmed/29716768
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.tibs.2018.03.007
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