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Why do disordered and structured proteins behave differently in phase separation?

Intracellular membraneless organelles and their myriad cellular functions have garnered tremendous recent interest. It is becoming well accepted that they form via liquid-liquid phase separation (LLPS) of protein mixtures (often including RNA), where the organelles correspond to a protein-rich, drop...

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Detalles Bibliográficos
Publicado en:Trends Biochem Sci
Autores principales: Zhou, Huan-Xiang, Nguemaha, Valery, Mazarakos, Konstantinos, Qin, Sanbo
Formato: Artigo
Lenguaje:Inglês
Publicado: 2018
Materias:
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC6014895/
https://ncbi.nlm.nih.gov/pubmed/29716768
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.tibs.2018.03.007
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