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Why do disordered and structured proteins behave differently in phase separation?

Intracellular membraneless organelles and their myriad cellular functions have garnered tremendous recent interest. It is becoming well accepted that they form via liquid-liquid phase separation (LLPS) of protein mixtures (often including RNA), where the organelles correspond to a protein-rich, drop...

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Detalhes bibliográficos
Publicado no:Trends Biochem Sci
Main Authors: Zhou, Huan-Xiang, Nguemaha, Valery, Mazarakos, Konstantinos, Qin, Sanbo
Formato: Artigo
Idioma:Inglês
Publicado em: 2018
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6014895/
https://ncbi.nlm.nih.gov/pubmed/29716768
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.tibs.2018.03.007
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