Osteocyte intrinsic TGFβ signaling regulates bone quality through perilacunar/canalicular remodeling

Poor bone quality contributes to bone fragility in diabetes, aging, and osteogenesis imperfecta. However, the mechanisms controlling bone quality are not well understood, contributing to the current lack of strategies to diagnose or treat bone quality deficits. TGFβ signaling is a crucial mechanism...

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Udgivet i:Cell Rep
Main Authors: Dole, Neha S., Mazur, Courtney M., Acevedo, Claire, Lopez, Justin P., Monteiro, David A., Fowler, Tristan W., Gludovatz, Bernd, Walsh, Flynn, Regan, Jenna N., Messina, Sara, Evans, Daniel S., Lang, Thomas F., Zhang, Bin, Ritchie, Robert O., Mohammad, Khalid S., Alliston, Tamara
Format: Artigo
Sprog:Inglês
Udgivet: 2017
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6014615/
https://ncbi.nlm.nih.gov/pubmed/29186693
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.celrep.2017.10.115
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