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Tissue growth constrained by extracellular matrix drives invagination during optic cup morphogenesis

In the early embryo, the eyes form initially as relatively spherical optic vesicles (OVs) that protrude from both sides of the brain tube. Each OV grows until it contacts and adheres to the overlying surface ectoderm (SE) via an extracellular matrix (ECM) that is secreted by the SE and OV. The OV an...

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Bibliographic Details
Published in:Biomech Model Mechanobiol
Main Authors: Oltean, Alina, Huang, Jie, Beebe, David C., Taber, Larry A.
Format: Artigo
Language:Inglês
Published: 2016
Subjects:
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC6014613/
https://ncbi.nlm.nih.gov/pubmed/26984743
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/s10237-016-0771-8
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