Induction of the Immunoproteasome Subunit Lmp7 Links Proteostasis and Immunity in α-Synuclein Aggregation Disorders

Accumulation of aggregated α-synuclein into Lewy bodies is thought to contribute to the onset and progression of dopaminergic neuron degeneration in Parkinson's disease (PD) and related disorders. Although protein aggregation is associated with perturbation of proteostasis, how α-synuclein aggr...

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Bibliografski detalji
Izdano u:EBioMedicine
Glavni autori: Ugras, Scott, Daniels, Malcolm J., Fazelinia, Hossein, Gould, Neal S., Yocum, Anastasia K., Luk, Kelvin C., Luna, Esteban, Ding, Hua, McKennan, Chris, Seeholzer, Steven, Martinez, Dan, Evans, Perry, Brown, Daniel, Duda, John E., Ischiropoulos, Harry
Format: Artigo
Jezik:Inglês
Izdano: Elsevier 2018
Teme:
Research Paper
Online pristup:https://ncbi.nlm.nih.gov/pmc/articles/PMC6014061/
https://ncbi.nlm.nih.gov/pubmed/29759483
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.ebiom.2018.05.007
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