Induction of the Immunoproteasome Subunit Lmp7 Links Proteostasis and Immunity in α-Synuclein Aggregation Disorders

Accumulation of aggregated α-synuclein into Lewy bodies is thought to contribute to the onset and progression of dopaminergic neuron degeneration in Parkinson's disease (PD) and related disorders. Although protein aggregation is associated with perturbation of proteostasis, how α-synuclein aggr...

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Veröffentlicht in:EBioMedicine
Hauptverfasser: Ugras, Scott, Daniels, Malcolm J., Fazelinia, Hossein, Gould, Neal S., Yocum, Anastasia K., Luk, Kelvin C., Luna, Esteban, Ding, Hua, McKennan, Chris, Seeholzer, Steven, Martinez, Dan, Evans, Perry, Brown, Daniel, Duda, John E., Ischiropoulos, Harry
Format: Artigo
Sprache:Inglês
Veröffentlicht: Elsevier 2018
Schlagworte:
Research Paper
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6014061/
https://ncbi.nlm.nih.gov/pubmed/29759483
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.ebiom.2018.05.007
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