Induction of the Immunoproteasome Subunit Lmp7 Links Proteostasis and Immunity in α-Synuclein Aggregation Disorders

Accumulation of aggregated α-synuclein into Lewy bodies is thought to contribute to the onset and progression of dopaminergic neuron degeneration in Parkinson's disease (PD) and related disorders. Although protein aggregation is associated with perturbation of proteostasis, how α-synuclein aggr...

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Dettagli Bibliografici
Pubblicato in:EBioMedicine
Autori principali: Ugras, Scott, Daniels, Malcolm J., Fazelinia, Hossein, Gould, Neal S., Yocum, Anastasia K., Luk, Kelvin C., Luna, Esteban, Ding, Hua, McKennan, Chris, Seeholzer, Steven, Martinez, Dan, Evans, Perry, Brown, Daniel, Duda, John E., Ischiropoulos, Harry
Natura: Artigo
Lingua:Inglês
Pubblicazione: Elsevier 2018
Soggetti:
Research Paper
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC6014061/
https://ncbi.nlm.nih.gov/pubmed/29759483
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.ebiom.2018.05.007
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