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Mechanistically informed predictions of binding modes for carbocation intermediates of a sesquiterpene synthase reaction

Sesquiterpenoids comprise a class of terpenoid natural products with thousands of compounds that are highly diverse in structure, generally containing a polycyclic carbon backbone that is constructed by a sesquiterpene synthase. Decades of experimental and computational studies have demonstrated tha...

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Pubblicato in:Chem Sci
Autori principali: O'Brien, T. E., Bertolani, S. J., Tantillo, D. J., Siegel, J. B.
Natura: Artigo
Lingua:Inglês
Pubblicazione: Royal Society of Chemistry 2016
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Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC6013805/
https://ncbi.nlm.nih.gov/pubmed/30155043
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1039/c6sc00635c
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