Inhibition of the key enzyme of sialic acid biosynthesis by C6-Se modified N-acetylmannosamine analogs

Synthetically accessible C6-analogs of N-acetylmannosamine (ManNAc) were tested as potential inhibitors of the bifunctional UDP-N-acetylglucosamine-2-epimerase/N-acetylmannosamine kinase (GNE/MNK), the key enzyme of sialic acid biosynthesis. Enzymatic experiments revealed that the modification intro...

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Foilsithe in:Chem Sci
Main Authors: Nieto-Garcia, Olaia, Wratil, Paul R., Nguyen, Long D., Böhrsch, Verena, Hinderlich, Stephan, Reutter, Werner, Hackenberger, Christian P. R.
Formáid: Artigo
Teanga:Inglês
Foilsithe: Royal Society of Chemistry 2016
Ábhair:
Chemistry
Rochtain Ar Líne:https://ncbi.nlm.nih.gov/pmc/articles/PMC6013775/
https://ncbi.nlm.nih.gov/pubmed/30155038
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1039/c5sc04082e
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