SIRT1 inhibits rheumatoid arthritis fibroblast-like synoviocyte aggressiveness and inflammatory response via suppressing NF-κB pathway

Rheumatoid arthritis (RA) is an autoimmune disease of the joints characterized by synovial hyperplasia and chronic inflammation. Fibroblast-like synoviocytes (FLS) play a central role in RA initiation, progression, and perpetuation. Prior studies showed that sirtuin 1 (SIRT1), a deacetylase particip...

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Vydáno v:Biosci Rep
Hlavní autoři: Li, Guoqing, Xia, Zhongbing, Liu, Ying, Meng, Fanru, Wu, Xia, Fang, Yuxuan, Zhang, Chunwang, Liu, Dan
Médium: Artigo
Jazyk:Inglês
Vydáno: Portland Press Ltd. 2018
Témata:
Research Articles
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC6013706/
https://ncbi.nlm.nih.gov/pubmed/29784872
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1042/BSR20180541
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