SIRT1 inhibits rheumatoid arthritis fibroblast-like synoviocyte aggressiveness and inflammatory response via suppressing NF-κB pathway

Rheumatoid arthritis (RA) is an autoimmune disease of the joints characterized by synovial hyperplasia and chronic inflammation. Fibroblast-like synoviocytes (FLS) play a central role in RA initiation, progression, and perpetuation. Prior studies showed that sirtuin 1 (SIRT1), a deacetylase particip...

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Bibliographic Details
Published in:Biosci Rep
Main Authors: Li, Guoqing, Xia, Zhongbing, Liu, Ying, Meng, Fanru, Wu, Xia, Fang, Yuxuan, Zhang, Chunwang, Liu, Dan
Format: Artigo
Language:Inglês
Published: Portland Press Ltd. 2018
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Research Articles
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC6013706/
https://ncbi.nlm.nih.gov/pubmed/29784872
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1042/BSR20180541
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