T Cell Repertoire Maturation Induced by Persistent and Latent Viral Infection Is Insufficient to Induce Costimulation Blockade Resistant Organ Allograft Rejection in Mice

CD28:CD80/86 pathway costimulation blockade (CoB) with the CD80/86-specific fusion protein CTLA4-Ig prevents T cell-mediated allograft rejection in mice. However, in humans, transplantation with CoB has been hampered by CoB-resistant rejection (CoBRR). CoBRR has been attributed in part to pathogen-d...

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Detalhes bibliográficos
Publicado no:Front Immunol
Main Authors: Espinosa, Jaclyn R., Mou, Danny, Adams, Bartley W., DiBernardo, Louis R., MacDonald, Andrea L., McRae, MacKenzie, Miller, Allison N., Song, Mingqing, Stempora, Linda L., Wang, Jun, Iwakoshi, Neal N., Kirk, Allan D.
Formato: Artigo
Idioma:Inglês
Publicado em: Frontiers Media S.A. 2018
Assuntos:
Immunology
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6013589/
https://ncbi.nlm.nih.gov/pubmed/29963060
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fimmu.2018.01371
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