Systemic Acrolein Elevations in Mice With Experimental Autoimmune Encephalomyelitis and Patients With Multiple Sclerosis

Demyelination and axonal injury are the key pathological processes in multiple sclerosis (MS), driven by inflammation and oxidative stress. Acrolein, a byproduct and instigator of oxidative stress, has been demonstrated as a neurotoxin in experimental autoimmune encephalomyelitis (EAE), an animal mo...

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Bibliographic Details
Published in:Front Neurol
Main Authors: Tully, Melissa, Tang, Jonathan, Zheng, Lingxing, Acosta, Glen, Tian, Ran, Hayward, Lee, Race, Nicholas, Mattson, David, Shi, Riyi
Format: Artigo
Language:Inglês
Published: Frontiers Media S.A. 2018
Subjects:
Neurology
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC6013577/
https://ncbi.nlm.nih.gov/pubmed/29963001
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fneur.2018.00420
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