DIPG-42. CAN WE CHANGE THE LANDSCAPE OF PEDIATRIC DIFFUSE INTRINSIC PONTINE GLIOMA (DIPG)? FIRST DEMONSTRATION OF CLINICAL AND RADIOGRAPHIC RESPONSE IN A PEDIATRIC H3-K27M MUTATED DIPG TO THE DRD2-ANTAGONIST ONC201

INTRODUCTION: DIPG is uniformly fatal, with a median survival of 8–9 months. We report the first pediatric patient with H3-K27M mutated DIPG treated with conventional radiotherapy and the small molecule DRD2-antagonist ONC201, with a sustained radiographic and clinical response after 8 months of the...

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Vydáno v:Neuro Oncol
Hlavní autoři: Hall, Matthew, Odia, Yazmin, Allen, Joshua, Tarapore, Rohinton, Khatib, Ziad, Maher, Ossama, Niazi, Toba, Daghistani, Doured, Schalop, Lee, Chi, Andrew, Oster, Wolfgang, Mehta, Minesh
Médium: Artigo
Jazyk:Inglês
Vydáno: Oxford University Press 2018
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On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC6012972/
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/neuonc/noy059.135
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