TBIO-21. ANALYSIS OF PAIRED BRAF(V600E) MUTANT GLIOMA PATIENT SAMPLES IDENTIFIES NOVEL RESISTANCE MECHANISMS TO TARGETED BRAF INHIBITION

BRAF(V600E) mutations occur in a variety of gliomas and BRAF(V600E) targeted therapies have provided new treatment options. Trials in melanoma and colorectal cancer, as well as early results in CNS tumors, indicate a high risk for the development of resistance. To date there is little data available...

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Veröffentlicht in:Neuro Oncol
Hauptverfasser: Levy, Jean Mulcahy, Sanford, Bridget, Morin, Andrew, Green, Adam, Flannery, Patrick, Jones, Kenneth, Banerjee, Anurhada, Nazemi, Kellie, Samuel, David, Kilburn, Lindsay, Solomon, David, Nicolaides, Theodore
Format: Artigo
Sprache:Inglês
Veröffentlicht: Oxford University Press 2018
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Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6012902/
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/neuonc/noy059.709
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