DIPG-24. TARGETED INHIBITION OF JMJD3 AND BET BROMODOMAIN PROTEINS FOR THE TREATMENT OF DIFFUSE INTRINSIC PONTINE GLIOMAS

Recent discovery of somatic histone gene mutations, resulting in replacement of lysine 27 by methionine (K27M) in the encoded histone H3.3 proteins, in diffuse intrinsic pontine glioma (DIPG) has improved our understanding of disease pathogenesis, and stimulated the development of novel therapeutic...

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Publicado en:Neuro Oncol
Main Authors: Katagi, Hiroaki, Louis, Nundia, He, Xingyao, Loughlin, Kathryn, Zhang, Ali, Ozark, Patrick, Horbinski, Craig, Lulla, Rishi, Saratsis, Amanda, Goldman, Stewart, David James, C, Shilatifard, Ali, Hashizume, Rintaro
Formato: Artigo
Idioma:Inglês
Publicado: Oxford University Press 2018
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Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC6012878/
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/neuonc/noy059.117
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