EPEN-34. HIGH-THROUGHPUT DRUG SCREENING OF PRIMARY CULTURES REVEALS IRREVERSIBLE ERBB2 INHIBITION AS NOVEL THERAPEUTIC VULNERABILITY OF EPENDYMOMAS

Ependymoma is the third most common brain tumor in children. Subsets of ependymomas, in particular RELA fusion-positive supratentorial ependymomas and posterior fossa type A ependymomas, are associated with frequent recurrence and dismal outcome. Neurosurgical resection and radiotherapy are the main...

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Publicado en:Neuro Oncol
Autores principales: Pauck, David, Sarikaya-Seiwert, Sevgi, Marquardt, Viktoria, Picard, Daniel, Bartl, Jasmin, Blümel, Lena, Maue, Mara, Dimitriadis, Christian, Kuhlen, Michaela, Fischer, Ute, Steiger, Hans-Jakob, Reifenberger, Guido, Borkhardt, Arndt, Beez, Thomas, Remke, Marc
Formato: Artigo
Lenguaje:Inglês
Publicado: Oxford University Press 2018
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Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC6012724/
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/neuonc/noy059.234
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