HGG-15. PHASE 2 NESTED COHORT STUDY OF DEPATUXIZUMAB MAFODOTIN IN CHILDREN WITH HIGH GRADE GLIOMA AND DIFFUSE INTRINSIC PONTINE GLIOMA WITH EGFR AMPLIFICATION

INTRODUCTION: Pediatric high grade gliomas (HGGs) and diffuse intrinsic pontine gliomas have no adequate therapy and are almost universally fatal. Depatuxizumab mafodotin (depatux-m) is an antibody-drug conjugate, comprised of anti-EGFR antibody linked to a microtubule cytotoxin, monomethyl auristat...

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Vydáno v:Neuro Oncol
Hlavní autoři: van den Bent, Martin, Dinjens, Winand, Golfinopoulos, Vassilis, Ansell, Peter, Dungey, Fiona, de Geus, Jan Peter, Bain, Earle, Looman, Jim, Xiong, Hao, Hargrave, Darren
Médium: Artigo
Jazyk:Inglês
Vydáno: Oxford University Press 2018
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On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC6012602/
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/neuonc/noy059.287
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