DIPG-36. ANTI-GD2 CHIMERIC ANTIGEN RECEPTOR T CELLS AS A POTENT IMMUNOTHERAPY REGIMEN IN XENOGRAFT MODELS OF HISTONE 3 K27M MUTANT DIFFUSE MIDLINE GLIOMA

Diffuse intrinsic pontine glioma (DIPG) and other histone H3 K27M (H3K27M) mutated diffuse midline gliomas (DMGs) are aggressive and universally fatal pediatric brain cancers. Chimeric antigen receptor (CAR)-expressing T-cells have mediated impressive clinical activity in B-cell malignancies, and re...

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Published in:Neuro Oncol
Main Authors: Mount, Christopher, Majzner, Robbie, Sundaresh, Shree, Arnold, Evan, Kadapakkam, Meena, Haile, Samuel, Labanieh, Louai, Woo, Pamelyn, Rietberg, Skyler, Vogel, Hannes, Monje, Michelle, Mackall, Crystal
Format: Artigo
Language:Inglês
Published: Oxford University Press 2018
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Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC6012589/
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/neuonc/noy059.129
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