MBRS-22. EZH2 OVEREXPRESSION INCREASES THE ONCOGENIC CHARACTER OF CEREBELLAR PROGENITORS AND ISOGRAFTS IN MICE RESULT IN TUMORS RESEMBLING GROUP 3 MEDULLOBLASTOMA

Previous studies have shown that EZH2, an epigenetic developmental regulator, is overexpressed in medulloblastoma. EZH2 is known to repress developmental genes in embryonic stem cells to maintain their stem cell characteristics. To identify the transcriptional networks that may be driving medullobla...

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Publicado en:Neuro Oncol
Autores principales: Sola, Ismail, Venkataraman, Sujatha, Pierce, Angela, Balakrishnan, Ilango, Birks, Diane, Foreman, Nicholas K, Vibhakar, Rajeev
Formato: Artigo
Lenguaje:Inglês
Publicado: Oxford University Press 2018
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Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC6012260/
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/neuonc/noy059.467
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