EPEN-13. NOVEL LSD-1 INHIBITOR VALIDATION IN NEWLY ESTABLISHED PFA EPENDYMOMA PATIENT-DERIVED ORTHOTOPIC XENOGRAFT (PDOX) MODELS

BACKGROUND: Posterior fossa A (PFA) ependymoma (EPN) has one of the worst prognosis in children and is primarily driven by epigenetic changes. In this study, we established a series of PFA EPN PDOX models from fresh surgical patient specimens. We also examined the therapeutic efficacy of SYC-836, a...

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Publicado en:Neuro Oncol
Autores principales: Zhao, Sibo, Zhang, Huiyuan, Qi, Lin, Lindsay, Holly, Du, Yuchen, Braun, Frank, Kogiso, Mari, Injac, Sarah, Song, Yongcheng, Li, Xiao-Nan
Formato: Artigo
Lenguaje:Inglês
Publicado: Oxford University Press 2018
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Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC6012242/
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/neuonc/noy059.214
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