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DIPG-60. PPM1D MUTATION MEDIATES TUMORIGENESIS AND IS A THERAPEUTIC TARGET IN DIFFUSE INTRINSIC PONTINE GLIOMA (DIPG)
While diffuse intrinsic pontine glioma (DIPG), the most common pediatric brainstem tumor, exhibits transient responsiveness to radiation (XRT), overall survival is <2% within two years of diagnosis. PPM1D is a serine/threonine protein phosphatase that is important in DNA damage response (DDR). Bu...
שמור ב:
| הוצא לאור ב: | Neuro Oncol |
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| Main Authors: | , , , , , |
| פורמט: | Artigo |
| שפה: | Inglês |
| יצא לאור: |
Oxford University Press
2018
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| נושאים: | |
| גישה מקוונת: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6012088/ https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/neuonc/noy059.153 |
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