MBRS-15. MELK INHIBITION AS A POTENTIAL THERAPEUTIC STRATEGY AGAINST ALL MOLECULAR SUBTYPES OF MEDULLOBLASTOMA

BACKGROUND: Medulloblastoma (MB) is the most common malignant embryonal brain tumors found among children. We found Maternal Embryonic Leucine Zipper Kinase (MELK), an oncogenic serine/threonine protein kinase, capable of disrupting critical cell cycle checkpoints leading to uncontrolled tumor growt...

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Vydáno v:Neuro Oncol
Hlavní autoři: Ho, Jia-Min, Lim, Zhi-Han, Karthik, Sekar, Su, Jack M, Lin, Qi, Du, YuChen, Shen, Jianhe, Chow, Wing-Yuk, Lau, Ching C, Adekunle, Adesina, Major, Angela, Tarek Elghetany, M, Li, Xiaonan, Hui, Kam-Man, Teo, Wan-Yee
Médium: Artigo
Jazyk:Inglês
Vydáno: Oxford University Press 2018
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On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC6011981/
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/neuonc/noy059.460
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