LGG-59. REMARKABLE OBJECTIVE RESPONSE AND FAVORABLE SURVIVAL FOR BRAF-V600E CHILDHOOD LOW-GRADE GLIOMAS TO BRAF INHIBITORS COMPARED CONVENTIONAL CHEMOTHERAPY

Activation of the MAPK pathway represents a hallmark of pediatric low-grade glioma (pLGG) and is frequently caused by BRAF alterations. BRAF-V600E represent an aggressive type of pLGG with less than optimal response to conventional chemo-radiation approaches. While clinical trials using BRAF-V600E i...

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Bibliografske podrobnosti
izdano v:Neuro Oncol
Main Authors: Zapotocky, Michal, Ryall, Scott, Fukuoka, Kohei, Stucklin, Ana Guerreiro, Bennett, Julie, Sumerauer, David, Pavelka, Zdenek, Cruz, Ofelia, Solano, Palma, Garre, Maria Luisa, Hauser, Peter, Frappaz, Didier, Hansford, Jordan, Amayiri, Nisreen, Morse, Helena, Sabel, Magnus, Bechensteen, Anne Grete, Su, Jack, Karajannis, Matthias, Finlay, Jonathan, Eisenstat, David, Canete, Adela, Toledano, Helen, Dahiya, Sonika, Leary, Sarah, Nicolaides, Theodore, Finch, Elisabeth, Mueller, Sabine, Levy, Jean Mulcahy, Ellison, David, Lassaletta, Alvaro, Larouche, Valerie, Ramaswamy, Vijay, Dirks, Peter, McKeown, Tara, Bartels, Ute, Bouffet, Eric, Hawkins, Cynthia, Tabori, Uri
Format: Artigo
Jezik:Inglês
Izdano: Oxford University Press 2018
Teme:
Abstracts
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC6011906/
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/neuonc/noy059.399
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