Distinct Mechanisms of Nuclease-Directed DNA-Structure-Induced Genetic Instability in Cancer Genomes

Sequences with the capacity to adopt alternative DNA structures have been implicated in cancer etiology; however, the mechanisms are unclear. For example, H-DNA-forming sequences within oncogenes have been shown to stimulate genetic instability in mammals. Here, we report that H-DNA-forming sequence...

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Pubblicato in:Cell Rep
Autori principali: Zhao, Junhua, Wang, Guliang, del Mundo, Imee M., McKinney, Jennifer A., Lu, Xiuli, Bacolla, Albino, Boulware, Stephen B., Zhang, Changsheng, Zhang, Haihua, Ren, Pengyu, Freudenreich, Catherine H., Vasquez, Karen M.
Natura: Artigo
Lingua:Inglês
Pubblicazione: 2018
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Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC6011834/
https://ncbi.nlm.nih.gov/pubmed/29386108
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.celrep.2018.01.014
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