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Distinct DNA repair pathways cause genomic instability at alternative DNA structures
Alternative DNA structure-forming sequences can stimulate mutagenesis and are enriched at mutation hotspots in human cancer genomes, implicating them in disease etiology. However, the mechanisms involved are not well characterized. Here, we discover that Z-DNA is mutagenic in yeast as well as human...
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| Publicado no: | Nat Commun |
|---|---|
| Main Authors: | , , , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
Nature Publishing Group UK
2020
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6957503/ https://ncbi.nlm.nih.gov/pubmed/31932649 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41467-019-13878-9 |
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