WDR5 supports colon cancer cells by promoting methylation of H3K4 and suppressing DNA damage

BACKGROUND: KMT2/MLL proteins are commonly overexpressed or mutated in cancer and have been shown to support cancer maintenance. These proteins are responsible for methylating histone 3 at lysine 4 and promoting transcription and DNA synthesis; however, they are inactive outside of a multi-protein c...

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Podrobná bibliografie
Vydáno v:BMC Cancer
Hlavní autoři: Neilsen, Beth K., Chakraborty, Binita, McCall, Jamie L., Frodyma, Danielle E., Sleightholm, Richard L., Fisher, Kurt W., Lewis, Robert E.
Médium: Artigo
Jazyk:Inglês
Vydáno: BioMed Central 2018
Témata:
Research Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC6011590/
https://ncbi.nlm.nih.gov/pubmed/29925347
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s12885-018-4580-6
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