A Functional Signature Ontology (FUSION) screen detects an AMPK inhibitor with selective toxicity toward human colon tumor cells

AMPK is a serine threonine kinase composed of a heterotrimer of a catalytic, kinase-containing α and regulatory β and γ subunits. Here we show that individual AMPK subunit expression and requirement for survival varies across colon cancer cell lines. While AMPKα1 expression is relatively consistent...

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Publicado no:Sci Rep
Main Authors: Das, Binita, Neilsen, Beth K., Fisher, Kurt W., Gehring, Drew, Hu, Youcai, Volle, Deanna J., Kim, Hyun Seok, McCall, Jamie L., Kelly, David L., MacMillan, John B., White, Michael A., Lewis, Robert E.
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group UK 2018
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5830883/
https://ncbi.nlm.nih.gov/pubmed/29491475
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41598-018-22090-6
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