Using Functional Signature Ontology (FUSION) to Identify Mechanisms of Action for Natural Products

A challenge for biomedical research is the development of pharmaceuticals that appropriately target disease mechanisms. Natural products can be a rich source of bioactive chemicals for medicinal applications but can act through unknown mechanisms and can be difficult to produce or obtain. To address...

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Main Authors: Potts, Malia B., Kim, Hyun Seok, Fisher, Kurt W., Hu, Youcai, Carrasco, Yazmin P., Bulut, Gamze Betul, Ou, Yi-Hung, Herrera-Herrera, Mireya L., Cubillos, Federico, Mendiratta, Saurabh, Xiao, Guanghua, Hofree, Matan, Ideker, Trey, Xie, Yang, Huang, Lily Jun-shen, Lewis, Robert E., MacMillan, John B., White, Michael A.
Format: Artigo
Jezik:Inglês
Izdano: 2013
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Article
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC4075427/
https://ncbi.nlm.nih.gov/pubmed/24129700
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1126/scisignal.2004657
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