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Telomere dysfunction triggers extensive DNA fragmentation and evolution of complex chromosome abnormalities in human malignant tumors

Although mechanisms for chromosomal instability in tumors have been described in animal and in vitro models, little is known about these processes in man. To explore cytogenetic evolution in human tumors, chromosomal breakpoint profiles were constructed for 102 pancreatic carcinomas and 140 osteosar...

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Published in:Proc Natl Acad Sci U S A
Main Authors: Gisselsson, David, Jonson, Tord, Petersén, Åsa, Strömbeck, Bodil, Dal Cin, Paola, Höglund, Mattias, Mitelman, Felix, Mertens, Fredrik, Mandahl, Nils
Format: Artigo
Language:Inglês
Published: National Academy of Sciences 2001
Subjects:
Biological Sciences
Online Access:https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC60114/
https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/11675499/
https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.211357798
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