Telomere dysfunction triggers extensive DNA fragmentation and evolution of complex chromosome abnormalities in human malignant tumors

Although mechanisms for chromosomal instability in tumors have been described in animal and in vitro models, little is known about these processes in man. To explore cytogenetic evolution in human tumors, chromosomal breakpoint profiles were constructed for 102 pancreatic carcinomas and 140 osteosar...

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Detalles Bibliográficos

Publicado en:	Proc Natl Acad Sci U S A
Principais autores:	Gisselsson, David, Jonson, Tord, Petersén, Åsa, Strömbeck, Bodil, Dal Cin, Paola, Höglund, Mattias, Mitelman, Felix, Mertens, Fredrik, Mandahl, Nils
Formato:	Artigo
Idioma:	Inglês
Publicado:	National Academy of Sciences 2001
Assuntos:	Biological Sciences
Acceso en liña:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC60114/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/11675499/ https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.211357798
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