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Telomere dysfunction triggers extensive DNA fragmentation and evolution of complex chromosome abnormalities in human malignant tumors

Although mechanisms for chromosomal instability in tumors have been described in animal and in vitro models, little is known about these processes in man. To explore cytogenetic evolution in human tumors, chromosomal breakpoint profiles were constructed for 102 pancreatic carcinomas and 140 osteosar...

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Veröffentlicht in:Proc Natl Acad Sci U S A
Hauptverfasser: Gisselsson, David, Jonson, Tord, Petersén, Åsa, Strömbeck, Bodil, Dal Cin, Paola, Höglund, Mattias, Mitelman, Felix, Mertens, Fredrik, Mandahl, Nils
Format: Artigo
Sprache:Inglês
Veröffentlicht: National Academy of Sciences 2001
Schlagworte:
Biological Sciences
Online-Zugang:https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC60114/
https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/11675499/
https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.211357798
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