The TLR4‐IRE1α pathway activation contributes to palmitate‐elicited lipotoxicity in hepatocytes

Lipotoxicity induced by saturated fatty acids (SFAs) plays a pathological role in the development of non‐alcoholic fatty liver disease (NAFLD); however, the exact mechanism(s) remain to be clearly elucidated. Toll‐like receptor (TLR) 4 plays a fundamental role in activating the innate immune system....

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Udgivet i:J Cell Mol Med
Main Authors: Shen, Chen, Ma, Wang, Ding, Lei, Li, Songtao, Dou, Xiaobing, Song, Zhenyuan
Format: Artigo
Sprog:Inglês
Udgivet: John Wiley and Sons Inc. 2018
Fag:
Original Articles
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6010797/
https://ncbi.nlm.nih.gov/pubmed/29673059
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/jcmm.13636
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