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Escherichia coli β-clamp slows down DNA polymerase I dependent nick translation while accelerating ligation
The nick translation property of DNA polymerase I (Pol I) ensures the maturation of Okazaki fragments by removing primer RNAs and facilitating ligation. However, prolonged nick translation traversing downstream DNA is an energy wasting futile process, as Pol I simultaneously polymerizes and depolyme...
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| Veröffentlicht in: | PLoS One |
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| Hauptverfasser: | , , , |
| Format: | Artigo |
| Sprache: | Inglês |
| Veröffentlicht: |
Public Library of Science
2018
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| Schlagworte: | |
| Online Zugang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6010275/ https://ncbi.nlm.nih.gov/pubmed/29924849 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0199559 |
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